منابع مشابه
VALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملIs Valproic Acid Ototoxic?
7 A forum for case studies, clinical notes and observations, and other clinical material that does not have a traditional research format. V alproic acid (VPA), or valproate, was first discovered in 1882 by Burton, but its anticonvulsant properties were not Although thousands of patients have been treated with VPA, only recently has the question of VPA ototoxicity been raised. The first reports...
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During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may...
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Precocious puberty refers to the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. In girls, the telltale signs of precocious puberty include any of the following symptoms before 7 or 8 years of age: breast development, pubic or underarm hair development, rapid height growth a growth "spurt", onset of menstruation, acne and "mature" b...
متن کاملValproic acid in Sydenham's chorea.
probable diagnosis of osteomalacia. The extremely low plasma 25-hydroxy vitamin D (25-OHD) concentration confirmed the diagnosis. Calciferol replacement treatment 3000 units daily was started. Two months later a mean unilateral hearing improvement of 12 db was apparent. A 49-year-old vagrant Irish ex-labourer was admitted in a state of confusion , dishevelment, and dehydration. One year previou...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2007
ISSN: 1933-7213,1878-7479
DOI: 10.1016/j.nurt.2006.11.007